Is Independent of Cyclic AMP
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چکیده
Infusion of forskolin, an adenylate cyclase activator, in concentrations (2 ,uM) that do not alter basal prostaglandin (PG) synthesis inhibit synthesis of PG elicited by isoproterenol in rabbit heart. This inhibitory action of forskolin appears to be dependent on cyclicAMP (cAMP). Bolus injection of forskolin (75 nmol), however, was found to stimulate PG synthesis in rabbit heart. The purpose of this study was to elucidate the mechanism of the stimulatory action of forskolin
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تاریخ انتشار 2005